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Increased thyroid stimulating hormone (TSH) as a possible risk factor for atherosclerosis in subclinical hypothyroidism | Thyroid Research | Springer Nature Link

Newman and colleagues developed one of the first LC-MS profiling methods for linoleate and arachidonate derived epoxides and vicinal diols in 2002, 417 measuring 13 oxylipins in 31 min with LOQ ⩽1.5 nM

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Genetics can also play a role, with some people naturally having less facial fat, making them more prone to a hollow or gaunt appearance as they get older