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NAD+ is the coenzyme that powers that process, but levels naturally decline with age, reducing the brain’s ability to produce energy and repair cellular damage

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in: Journal of Molecular Biology , 267 (1997)4, 1039-1052) Previous studies of model peptides have also shown that salt bridges spaced at i,i +4 along the peptide chain are more stabilizing than those spaced at i,i +3, with a preference for the order acid-base rather than base-acid from the N- to the C- terminus

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