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An imbalance in phosphorylation levels can slow axonal transport, leading to aggregation of neurofilaments
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The team constructed a radioimmunoconjugate in which an integral membrane glycoprotein-targeting mAb, ChL6, was linked to an [ 111 In]In-DOTA moiety via this cleavable linker and found that this probe was immunoreactive, stable in serum, andcriticallycould be cleaved efficiently by clinical doses of TNKase in vitro
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