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Arsenic exposure enhances oxidative stress by the depletion of GSH and the impairment of ROS-scavenging enzymes [46,51]
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6.3 Alcohol Alcoholic liver disease patients have low hepatic and plasma GSH levels due to multiple mechanisms such as oxidative stress, nutritional deficiency and abnormalities in the methionine metabolic pathway that impairs cysteine availability [164–166]
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