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Placental proteins as biomarkers for early diagnosis of Preeclampsia There is a necessity to identify and establish gestational biomarkers that can be employed for monitoring pregnancies, and predicting adverse outcomes

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Readouts should triangulate source and compartment by using matrix/IMS-targeted reporters for H 2 O 2 dynamics, peroxiredoxin-3 (Prx3) redox state as a fast sentinel of matrix oxidant load and functional recovery after stress (e.g., respiration, contractility, cell survival) to confirm that interventions restore signalling–damage balance rather than merely lower bulk ROS (Cardozo et al