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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Calabrese G., Ardizzone A., Campolo M., Conoci S., Esposito E., Paterniti I

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Other studies have shown that HFD-driven lipid overload in follicular environments disrupts somatic-germ cell interactions, initiating mitochondrial and ER dysfunction within the follicle ( 3.3.2 Metabolic inflammation and ROS production Metabolic inflammation, characterized by adipokine dysregulation and systemic insulin resistance, is a hallmark of HFD and a key driver of ROS overproduction in ovarian tissue