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A review of individual studies found that people with lower serum vitamin B12 levels are at a higher risk for depression
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Greco and colleagues, in Bioconjugate Chemistry in 2025, synthesised hyaluronan conjugates of GHK at several peptide loadings, showed that they bind copper(II), and reported expression and release of brain-derived neurotrophic factor, vascular endothelial growth factor and bone morphogenetic protein-2, linked to nuclear translocation of the copper chaperones CCS and Atox1
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