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Consequently, the CPPO payload reacts with H 2 O 2 producing chemical energy to activate Ce6 to generate singlet cytotoxic oxygen ( 1 O 2 ) for tumor cells apoptosis in patient derived as well as cell derived GBM in vivo studies
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Additionally, prospective clinical cohort studies and early-phase clinical trials should be conducted, prioritizing the validation of intervention targets that exhibit manageable safety profiles and relatively clear mechanisms
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