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Administration of the ED 80 po antinociceptive dose of mitragynine resulted in detection of 0.094 ± 0.03 and 0.035 ± 0.01 μ M concentrations of 3DM in the brains of C57BL/6J and 129Sv6 mice, respectively, coinciding with concentrations of 0.037 ± 0.01 and 0.028 ± 0.01 μ M in plasma of C57BL/6J and 129Sv6 mice, respectively (Figure 7D)

PACK3+1

SIZE:1 GALLON

The increase in MDA correlated significantly with decrease in the antioxidant capacity of the plasma during human aging, confirming that the decrease in antioxidant power in body is a reason for increased oxidative stress during aging.42 Since the measurement of MDA is easy and fast to perform and the results are very reproducible, it is one of the most important biomarkers for the evaluation of the status of lipid peroxidation and is a biomarker of aging