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On a mechanistic level, the “Psychedelic Iatrogenic Structural Dissociation” (PISD) hypothesis proposes that these substances may lower the defensive barriers between the part of the personality that handles daily life (the “Apparently Normal Personality”) and the part that holds traumatic memories (the “Emotional Personality”), leading to psychological destabilization, emotional dysregulation, and identity fragmentation in individuals with histories of trauma [117,118,119]

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