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Researchers have developed a dominant-negative form of ATF5 (dn-ATF5) by deleting its N-terminal activation domain while retaining the bZIP dimerization and DNA-binding regions and further conjugated it to an HIV-TAT sequence to generate a cell-permeable synthetic peptide (CP-dn-ATF5) (234,235)
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This compound can degrade biological macromolecules such as proteins, enzymes, lipids, carbohydrates, and nucleic acids by generating OH· radicals
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