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However, three studies identified the decreased levels of alanine in the plasma and CSF of PD patients 32,92,93 , two of which involved genetic PD patients, including PARK2 32 and LRRK2 92 PD patients

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What follows is an attempt to take into account these two roots (purely physiological and interoceptive) of pathological fatigue, and to try deciphering how they interact with each other