does ethanol deplete glutathione 1 Description of enzymes that participate in metabolism Oxidative stress

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These findings have inspired new therapeutic strategies, particularly through nanoparticle-mediated glutamine metabolism targeted therapy, which can effectively prevent M2-like cell polarization and enhance anti-tumor immune response by disrupting TAMs metabolic adaptation, regulating epigenetic regulation dependent on α-KG, and reducing GSH to restore M1-like tumor surveillance (104, 105)