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A factor influencing glutathione status is the degree of variability in an individual’s capacity to produce glutathione, mainly due to genetic variability in enzymes involved in its production and/or regeneration
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Over-expression of DJ-1 in SH-SY5Y cells results in increased Nrf2 protein levels, promotes its translocation to the nucleus and enhances its recruitment onto the antioxidant response element (ARE) in the promoter of the redox regulator thioredoxin-1 (Trx1)
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