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Their mechanisms are complementary rather than competitive, addressing different aspects of neural plasticity: Dihexa promotes the structural formation of new synaptic connections, while PE-22-28 enhances neuronal excitability and drives neurogenesis

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Another important finding is that the AChE activity which has been linked to the pathology of MS (Di Bari et al., 2016), was significantly decreased in mice treated with VA, IBD, and VA + IBD (Figure 6B) confirming the enhancement of remyelination