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3.2.2 TGF-Ξ²-induced mitochondrial ROS production Mitochondria are the primary intracellular source of ROS, and TGF-Ξ²1 markedly enhances their production across multiple cell types, contributing to apoptosis, senescence, epithelialβmesenchymal transition (EMT), and fibrotic gene expression associated with myofibroblast differentiation [58]
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