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[DOI] [PMC free article] [PubMed] [Google Scholar] 86.Leaf D.E., Body S.C., Muehlschlegel J.D

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Studies have shown that evodiamine (which increases acetylation levels by approximately 3–4-fold at a concentration of 5 μM) and paclitaxel (which induces peak acetylation within 30 min at 33 nM) both enhance NLRP3 inflammasome activation and subsequent pyroptosis by specifically promoting acetylation at lysine 40 (K40) of α-tubulin—a process dependent on the acetyltransferase MEC-17—thereby revealing their mechanisms of action in cancer therapy [283, 284]