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In a targeted DNA methylation study focusing on five genes involved in fibrogenesis modulation, the results showed hypomethylation of pro-fibrogenic genes (TGFฮฒ1 and PDGFฮฑ) and hypermethylation of anti-fibrogenic genes (PPARฮฑ and PPARฮด) in advanced MASLD compared to mild cases, suggesting that the methylation status of specific CpGs could potentially predict the severity and progression of MASLD to liver fibrosis [340]
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