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This delay is likely due to the time required for subsequent increases in renal IGF-1 levels, suggesting that locally produced IGF-1 may play a crucial role as a mediator of GH's renal effects.14 Of note, IGF-1 injection alone is sufficient to induce renal actions in animals with pituitary gland ablation, further supporting the importance of IGF-1 in this context.15,16 Additionally, IGF-1 administration led to an increase in GFR in healthy volunteers while simultaneously decreasing GH levels and insulin secretion

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Expert Opin Drug Metab Toxicol 2020;16:1039–50 [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Pakravan N, Waring WS, Sharma S, Ludlam C, Megson I, Bateman DN.Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose