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Figure 3 shows a few of the prominent HBOC designs based on direct chemical modification of cell‐free Hb, and Figure 2c shows representative O 2 ‐binding curves for such HBOC designs (e.g., Hemopure, Polyheme, and LtEc) demonstrating that these HBOCs indeed have sigmoid O 2 ‐binding kinetic curves similar to native RBC, but with some differences in kinetic profiles

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In addition, non-modifiable elements, such as inherited genetic mutations, DNA repair defects, hormonal imbalances, and immune dysfunction, further contribute to cancer risk

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