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[DOI] [PMC free article] [PubMed] [Google Scholar] 100.Song Y., Chen J., Liu K., Zhou K., Lu Y., Wang X., Yang Y., Liu X

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Where there have been delays or decisions not to submit at that earliest opportunity or through parallel processes, because of the PBAC's need for data certainty, our company may decide to delay that application until additional data become availabile to minimise that uncertainty or to conduct additional assessments to identify the population where the drug is most cost-effective.[61] 2.54 Submitters told the committee that greater collaboration is needed between each of the regulatory and reimbursement agencies with regard to the assessment of clinical evidence to enhance the efficiency of parallel processing.[62] The committee notes that the Review of Medicines and Medical Devices Regulation recognised the synergies between the TGA, the PBAC and the MSAC and considered that there would be benefits in considering organisational structures to facilitate improved integration of these functions across the lifecycle of medicines and medical devices.[63] 2.55 The committee notes that additional timing complexities are associated with the assessment of co-dependent technologies, and that there is a view that systems improvements have failed to address these: It is common for cancer medicines, particularly targeted medicines, to have an associated diagnostic test or treatment-associated device to ensure the medicine is used where most effective