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Future investigations on how the upstream Pb-induced inhibition of ALAD affects the next two inhibition steps might help better understand the mechanism of Pb toxicity and its association with ALAD polymorphism

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In HGSOC cells, iron metabolism is significantly interfered with, and therefore, iron uptake and retention increase, TFR1 expression of iron intake increases, iron efflux pump FPN expression is reduced and ferritin is relatively increased