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When examining the effects of BPC 157 on tail spasticity the results reported that development of spasticity began earlier in the test subjects treated with the peptide in comparison to the corresponding controls

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For example, in work by Jiang et al, a possible negative regulation of TGFβ1 (transforming growth factor beta 1) by Nrf2 activation was observed, raising the question of whether Nrf2 negatively regulates TGFβ1 expression by direct binding to the promoter region of its gene or by other, downstream effects