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The first are Treg and Th17 cells, as subpopulations of lymphocytes with opposite functions, whose balance is essential for inhibiting osteoclast activity and maintaining bone homeostasis ( via molecules including RANK, IL-7, and anti-OPG antibodies ( 3.2.2 How gut factors regulate bone health via immune system Except for the direct targeting of osteocytes as described above, intestinal factors also influence the distal bone tissue through the immune and inflammatory pathways
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