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Lateral to the middle scalene muscle the three trunks are formed: C5 and C6 combine into the upper trunk, C7 continues alone as the middle trunk, and C8 and T1 combine to form the lower trunk (Figures 2, 4)

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Cellular model, agonist, agonist concentration, time of exposure, level of OR expression or signaling pathway studied are among the different parameters that could influence OR desensitization as previously reviewed (Connor et al., Definition As indicated above, desensitization is defined as a progressive reduction of signal transduction that occurs more or less rapidly after OR activation depending on the agonist and the signaling pathway

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