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Astrocyte polarization toward an A1 or A2 phenotype is mainly controlled by the NFκB, toll-like receptors (TLRs), mitogen-activated protein kinase (MAPK) and the Janus kinase/STAT3 (JAK/STAT3) signaling pathway (Ding et al., 2021)
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Interestingly, a study on aging mice demonstrated that CoQ10, a mitochondrial cofactor, can effectively reverse most of these changes (Meldrum et al., 2016)
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