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Because of this, individuals supplementing this form of B12 often report improved quality of sleep, often will require slightly less sleep, and will not uncommonly report that they feel a bit more refreshed when waking in the morning B12 Deficiency Vegetarians and vegans are especially prone to Vitamin B12 deficiency but it they are not alone

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Some research suggests an interaction between NAD+ availability and antioxidant enzyme function, though this remains an active area of study