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[DOI] [PMC free article] [PubMed] [Google Scholar] 175.Li W., Chaudhari K., Shetty R., Winters A., Gao X., Hu Z., Ge W.P., Sumien N., Forster M., Liu R., et al
Innerlab
Size:3 BARS (4 OZ EA)
Molecular and Cellular Effects of Targeting CD38 Analyses of CD38 antibody mechanisms, primarily from preclinical myeloma models suggest that target cell depletion involves Fc-dependent immune effector processes, including complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), and antibody-dependent phagocytosis (ADCP) [27] Additional mechanisms may include interference with CD38’s ectoenzymatic activity, apoptosis induction, or triggering CD38-dependent activation, potentially affecting immune cells like NK cells, where overactivation may cause exhaustion or cell death
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