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In addition, ROS promote, among others, oxidative modifications of macromolecular compounds, including lipid peroxidation with the generation of among others 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA)
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TYP incited the autophagy-dependent degradation of ferritin and ROS accumulation by activating the MP-activated protein kinase (AMPK) signaling pathway and then inducing the ferroptosis of acute myeloid leukemia (AML) cells (Zhu et al., 2019)
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