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In breast cancer with genomic amplification of the serine biosynthesis gene phosphoglycerate dehydrogenase ( PHGDH ), PSAT1 is the major source of glutamine dependent Ξ±-ketoglutarate, through transamination,, and breast cancer cells with amplified PHGDH grow poorly after PHGDH depletion compared to those with normal levels 142 , underscoring the importance of these reactions in certain tumor types
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As we talked about with Alzheimerβs, it tends to fail because youβve got insulin resistance and because youβve got toxin exposure and things like that
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