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The expression of phosphorylated STAT3, JAK1, and JAK2 was also reduced (164), which reduced VEGF secretion and nuclear phosphorylated STAT3 translocation for CoCl2-stimulated HER2+ BT-474 cells ( Figure 2 )

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It was also observed that the particle size of encapsulated EVs-nob was larger than that of the original PLGA-nob, which is consistent with the findings of other research groups (Zhu et al., 2023)