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Pimavanserin: Pimavanserin, a 5-HT₂A inverse agonist used to treat hallucinations and delusions associated with PDP, is the only FDA-approved atypical antipsychotic for PDP [103]
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Targeted experimental validation was performed in murine myotubes/muscle tissue from mALD for mitochondrial oxidative function using high sensitivity respirofluorometry, structural evaluation of mitochondrial morphology using confocal microscopy, cristae morphology on 3D electron microscopy, HIF1a, and myostatin expression by immunoblots
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