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The most common method of inducing goiter in animals is through deficiency in iodine, since iodine is a critical element in thyroid hormone synthesis (Colque-Caro et al
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Intriguingly, characterization of the transcriptional response to cysteine deprivation has revealed glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) as the most highly induced gene 6
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