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The history of the development of the smart release system ( Table 3 ) indicates that the first generation of stimuli-responsive nanofertilizers (pH-responsive) was developed between 2016-2017 (127, 128), as a continuation of the properties of nanomaterial-plant contact (142)

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Indeed, in a study led by California’s Institute of Technology, the introduction of a viral infection to pregnant mice resulted in the birth of less sociable, more anxious baby mice