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People in the following categories should discuss alternatives with their provider: Those who are pregnant or breastfeeding Patients with active cancer (without oncology approval) Individuals with severe kidney or liver disease Patients on medications with potential interactions Those with a history of injection-site infections or poor healing A proper intake and medical review is standard before starting any injection protocol

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Significance for individual compounds was evaluated by pairwise Wilcoxon rank sum test (paired for HI-ipsilateral versus HI-contralateral, unpaired for other pairwise group comaprisons) and significance reported as p-values corrected for Bonferroni-Hochberg False Discovery Rate (FDR), alpha = 0.05

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