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Your brain runs on protection—and glutathione is at the center of it. Glutathione is your body's master antioxidant, playing a critical role in protecting brain cells from oxidative stress, supporting detoxification, and

Hum Mol Genet 29

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It was found that in the presence of 6-aminonicotinamide (6AN), G6PDH inhibitor, the level of G6P was almost doubled while ROS levels were reduced by a half, thus suggesting that ( i ) in CF cells G6P is preferentially metabolized through PPP and ( ii ) PPP-derived NADPH is likely to be the driving force to generate NOX-derived ROS, being the latter an enzyme whose activity overcomes that of GR [116] (see above, Section 5.2.2)