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(2022) have explored that the β-elemene integrated with erlotinib enhanced the cytotoxicity of erlotinib against EGFR mutated primary EGFR-TKI resistant NSCLC cells, and diminished the content of ferroptosis negative regulatory proteins (glutaminase, FTH1, Nrf2, Slc7a11 and GPX4), added ROS and lipid peroxidation levels, and accomplished anti-tumor effects through ferroptosis

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[12] It is further envisaged in the context of the present invention that the said third domain comprises an amino to carboxyl order: hinge-CH2 domain-CH3 domain-linker-hinge-CH2 domain-CH3 domain